The Pathway For

Non-conventional Antibiotic

The following characteristics help counter AMR development and issues related to the conventional pipeline:


  • Development costs should be about 1000 times less ($1 million versus $1 billion).
  • Having multiple mechanisms of action would help counter AMR.
  • Many effective, cheap, low toxicity compounds with well defined composition would be needed to achieve the above.
  • Plant based compounds, ie. botanicals could achieve the above. 
  • If the product were topical only, its safety profile would be further enhanced, decreasing therapeutic and commercial risk.
  • Microbial mechanisms of achieving resistance would have to be specifically countered.
  • The product would require particularly strong activity against the key pathogenic species. 
  • A non-prescription OTC (over the counter) pathway would be preferred.
  • If AMR development could be minimised, the product could be widely used, increasing commercial profitability and longevity. 
  • If the product were non-conventional, and synergies with conventional antibiotics could be established, this would greatly increase therapeutic and commercial value. 
  • Concurrent activity against pathogenic fungi would be highly advantageous in treating mixed infections, without the delay and cost of laboratory micro testing. 
  • The above being achieved would constitute a new antibiotic class.