The Pathway For
Non-conventional Antibiotic
The following characteristics help counter AMR development and issues related to the conventional pipeline:
- Development costs should be about 1000 times less ($1 million versus $1 billion).
- Having multiple mechanisms of action would help counter AMR.
- Many effective, cheap, low toxicity compounds with well defined composition would be needed to achieve the above.
- Plant based compounds, ie. botanicals could achieve the above.
- If the product were topical only, its safety profile would be further enhanced, decreasing therapeutic and commercial risk.
- Microbial mechanisms of achieving resistance would have to be specifically countered.
- The product would require particularly strong activity against the key pathogenic species.
- A non-prescription OTC (over the counter) pathway would be preferred.
- If AMR development could be minimised, the product could be widely used, increasing commercial profitability and longevity.
- If the product were non-conventional, and synergies with conventional antibiotics could be established, this would greatly increase therapeutic and commercial value.
- Concurrent activity against pathogenic fungi would be highly advantageous in treating mixed infections, without the delay and cost of laboratory micro testing.
- The above being achieved would constitute a new antibiotic class.